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There is a common notion that oral steroids are bad because they damage the liver and injectable steroids are good because they bypass the liverand enter the bloodstream.""We now have evidence that oral steroids, like many other drugs, can damage liver fibroblasts, and there is a link with damage to the liver. In rats, we found the injection of oral steroids for 12 weeks significantly accelerated fibroblast cell death."There was little difference between the two groups to their diet, and the liver cells appeared healthier.The researchers now believe that oral agents like glucocorticoids and insulin can damage the liver by stimulating the production of collagen. Compound 1 in the study is an insulin-like compound that may be linked to an increased risk of cardiovascular diseases like cardiovascular disease.The research team is now looking at the mechanism underlying their findings. The researchers are trying to pinpoint what happens to fibroblasts in the liver to account for the reported effects of oral steroids."We think the enzymes that can cause collagen breakdown that our group identifies are probably responsible," says Dr. Tzong. "That may explain other mechanisms for the effect."It may also help us identify how this works and why this occurs in mice. We need more work in human patients to determine if this is a real effect and what causes this change in fibroblasts."As well as causing fibrosis, oral steroids increase the levels of inflammatory molecules in the brain and liver. When inflammation occurs, fibroblasts die."What we're seeing is a significant risk of heart disease in people who took oral steroids. This is very interesting because of the effects on the heart," says Dr. John Phelan, associate professor of endocrinology in the School of Medicine who was not involved in the study."We know heart disease is associated with high fat diets and high cholesterol. These drugs seem to be causing high fat diets and high cholesterol, and a lot of it. I think our study is really important in making a connection between these drugs and heart disease."Additional contributors to this study include Prof. Ewan MacGregor and Dr. Michael K. Tashkin.Explore further: The body builds new blood vessels after oral steroidsRelated Article: